The development, commercialization, and clinical context of yttrium-90 radiolabeled resin and glass microspheres

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The development, commercialization, and clinical context of yttrium-90 radiolabeled resin and glass microspheres

Selective internal radiation therapy has emerged as a well-accepted therapeutic for primary and metastatic hepatic malignancies. This therapeutic modality requires the combined efforts of multiple medical disciplines to ensure the safe delivery of yttrium-90 (90Y)-labeled microspheres. The development of this therapy followed decades of clinical research involving tumor vascularity and microsph...

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BACKGROUND Many patients with liver malignancies are not candidates for resection, and systemic therapies are often not effective. Radioembolization (RE) is an alternative treatment for this group of patients. The safety and efficacy of RE with yttrium 90 (Y90) in patients with hepatocellular carcinoma (HCC) or metastatic colon cancer to the liver have been proven in several studies. However, f...

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ژورنال

عنوان ژورنال: Advances in Radiation Oncology

سال: 2016

ISSN: 2452-1094

DOI: 10.1016/j.adro.2016.08.003